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Research Projects

NASH Foundation Research Studies

Completed Studies

 

"A Comprehensive Approach to Manage Concussion in High School and Collegiate Athletes Utilizing IMPACT"

Investigator(s):
  • Carl C. Berasi, DO
  • Michael B. Cannone, DO
  • Timothy P. Duffey, DO
  • Mark E. Gittins, DO
  • Francis J. O'Donnell, DO
  • Scott M. Otis, MD
  • Sponsor(s):
  • OrthoNeuro Foundation

 

 

"Drug and Non-Drug Treatment of Severe Migraines"

Principal Investigator:
  • Ken Holroyd, PhD
Co-Investigator(s):
  • Francis J. O'Donnell, DO
  • Connie Cottrell, PhD
Sponsor(s):
  • National Institute for Health (NIH)

 

 

"Home-Based Behavioral Treatment of Migraines in Adolescents: A Pilot Study"

Principal Investigator:
  • Ken Holroyd, PhD
  • Co-Investigator(s):
  • Francis J. O'Donnell, DO
  • Connie Cottrell, PhD
Sponsor(s):
  • National Institute for Health (NIH)

 

 

"A Randomized, Double-Blind, Placebo Controlled, Parallel Groups, Outpatient Study to Examine the Safety, Tolerability, and Efficacy of Rizatriptan 5 mg P.O. for the Acute Treatment of Migraine in Adolescents"

Principal Investigator:
  • Francis J. O'Donnell, DO
  • Co-Investigator(s):
  • Connie Cottrell, PhD
Sponsor(s):
  • Merck

 

 

"A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Parallel-Groups, Outpatient Study to Examine the Safety, Tolerability, and Efficacy of Rofecoxib 50 mg and Concomitant Administration of Rofecoxib 50 mg Plus Rizatriptan 10 mg for the Acute Treatment of Migraine"

Principal Investigator:
  • Francis J. O'Donnell, DO
  • Co-Investigator(s):
  • Connie Cottrell, PhD
Sponsor(s):
  • Merck

 

 

"A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Evaluation of Sumatriptan 50mg and 100mg Tablets Administered During the Mild Pain Phase of a Menstrually-Associated Migraine Attack"

Principal Investigator:
  • Francis J. O'Donnell, DO
  • Co-Investigator(s):
  • Connie Cottrell, PhD
Sponsor(s):
  • GlaxoSmithKline

 

 

"Mechanical Testing of Demineralized Femoral/Fibular Rings"

Principal Investigator:
  • Alan S. Litsky, MD, ScD
Co-Investigator(s):
  • Daryl R. Sybert, DO
Sponsor(s):
  • OSU/OrthoNeuro Foundation
  • Status: Ongoing

 

 

"Joint Vibration Analysis"

Principal Investigator(s):
  • Mark E. Gittins, DO
  • Carl C. Berasi, DO
  • Presentation at ISAKOS

 

 

"Merck066: A multi-center, double-blind, randomized, parallel, placebo-controlled study to examine the efficacy of Rizatriptan 10 mg tablet administered early during a migraine attack while the pain is mild."

Principal Investigator(s):
  • Francis J. O'Donnell, DO
  • M.T. Taylor, DO, PhD
Sponsor:
  • Merck & Co., Inc.

 

 

"Pozen: A Double-Blind, Multi-center, Randomized, Placebo-Controlled Single Dose Study to Evaluate the Safety and Efficacy of TreximaTM in the Acute Treatment of Migraine Headaches"

Principal Investigator(s):
  • Francis J. O'Donnell, DO
  • M.T. Taylor, DO, PhD
Sponsor:
  • GlaxoSmithKline

 

 

"PROTOCOL SUM30047: "A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Attack Study to Evaluate the Onset of Efficacy of a New Formulation of Sumatriptan Tablets 50mg and 100mg in the Acute Treatment of Migraine"

Primary Investigator:
  • Francis J. O'Donnell, DO
Sponsor:
  • GlaxoSmithKline

 

 

"NPP30010: A multi-center, randomized, double-blind, placebo-controlled, parallel-group, study to evaluate the safety and efficacy of lamotrigine as add-on treatment in subjects with neuropathic pain and inadequate pain relief with gabapentin, tricyclic antidepressants or non-narcotic analgesics."

Primary Investigator:
  • M.T. Taylor, DO, PhD
Sponsor:
  • GlaxoSmithKline

 

 

"A 12-Week, Double-Blind, Placebo Controlled, Parallel Group Study to Assess the Efficacy and Safety of Ropinirol XR (Extended Release) in Patients with Restless Legs Syndrome."

Principal Investigators:
  • Francis J. O'Donnell, DO
  • M.T. Taylor, DO, PhD
Sponsor:
  • GlaxoSmithKline

 

 

"A multi-center, double-blind, randomized, parallel-group, placebo controlled study to evaluate the efficacy and tolerability of Rizatriptan 10 mg tablet for the treatment of Menstrual Migraine"

Principal Investigators:
  • Francis J. O'Donnell, DO
Sponsor:
  • Merck & Co., Inc.

 

 

"A randomized, double blind, multi-center, placebo-controlled, crossover study to determine the consistency of TREXIMA (Sumatriptan 85mg/naproxen sodium 500 mg) in the acute treatment of multiple migraines attacks."

Principal Investigators:
  • Francis J. O'Donnell, DO
  • M.T. Taylor, DO, PhD
Sponsor:
  • Pozen
  • GlaxoSmithKline

 

 

"A randomized, double-blind, single migraine attack, placebo-controlled, parallel-group multicenter study to evaluate the efficacy and tolerability of Trexima (sumatriptan succinate/naproxen sodium) tablets vs placebo when administered during the mild pain phase of menstrual migraine in women with dysmenorrhea."

Principal Investigators:
  • Francis J. O'Donnell, DO
Sponsor:
  • GlaxoSmithKline

"Memory and Stress Study"

Principal Investigator:
  • K. Heffner
Sponsor:
  • Ohio University

 

 

"Botox for the Treatment of Occipital Neuralgia"

Primary Investigator:
  • M.T. Taylor, DO, PhD
Sponsor:
  • Allergan

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Active Studies

"A Prospective, Randomized Clinical Investigation of the Cervitech, Inc. Porous Coated Motion Artificial Disc for Stabilization of the Cervical Spine between C3-C4 and C7-T1."

Primary Investigator:
  • Daryl R. Sybert, DO
Sponsor:
  • Cervitech, Inc

 

 

"Retrospective chart review of INFUSE Bone Graft"

Primary Investigator:
  • Daryl R. Sybert, DO
Sponsor:
  • Medtronic

 

 

"A Study of Combination Product (sumatriptan succinate and naproxen sodium) in Migraine Subjects who Report Poor Response or Intolerance to Eletriptan)"

Primary Investigator:
  • Francis J. O'Donnell, DO
Sponsor:
  • GlaxoSmithKline

 

 

"A 52-Week, Open-Label Study to Assess the Long-Term Safety of Ropinirole Extended Release (XR) in Patients with Restless Legs Syndrome (RLS)"

Primary Investigator:
  • M.T. Taylor, DO, PhD
Sponsor:
  • GlaxoSmithKline

 

 

"Keppra for the Treatment of Occipital Neuralgia: A Pilot Study"

Primary Investigator:
  • M.T. Taylor, DO, PhD
Sponsor:
  • UCB
  • Pharma

 

 

"Botulinum Toxin Type A Purified Neurotoxin Complex (BOTOX®) as a Headache Prophylaxis in Migraine Patients."

Primary Investigator:
  • M.T. Taylor, DO, PhD
Sponsor:
  • Allergan

 

 

"A randomized, double-blind, placebo-controlled study to determine the efficacy of Botulinum Toxin Type A for the Treatment of Plantar Fasciitis"

Primary Investigator:
  • M.T. Taylor, DO, PhD
Sponsor:
  • NASH Foundation
  • Allergan

 

 

"Project Insight (evaluating co-morbid mood disorders and migraine)"

Primary Investigators:
  • B.D. Heckman
  • Francis J. O'Donnell, DO
Sponsor:
  • Ohio Headache Association
  • NIH

 

 

"Validation of migraine specific assessment measures for adolescents."

Primary Investigators:
  • Ken Holroyd, PhD
  • Connie Cottrell, PhD
  • J.B. Drew, PhD
Sponsor:
  • Ohio University
  • NIH

 

 

"A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and tolerability of TREXIMA (sumatriptan succinate/naproxen sodium) for a single moderate or severe headache in adults diagnosed with probable migraine without aura."

Primary Investigator:
  • Francis J. O'Donnell, DO
Sponsor:
  • GlaxoSmithKline

 

 

"Discography after lumbar disc arthroplasty"

Primary Investigators:
  • D. Peery, DO
  • Daryl R. Sybert, DO
  • L.T. Todd, DO

 

 

"Cervical Disc arthroplasty with the PCM artificial disc"

Primary Investigators:
  • Y. Chen, DO
  • D. Peery, DO
  • Daryl R. Sybert, DO
Sponsor:
  • Cervitech, Inc.

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